It is also a key element of intracellular transport, which is critical for axonal development and neurotrophic signaling, but which is also disrupted in many, if not all neurodegenerative diseases. The interactive format of the workshop will allow speakers as well as participants from largely separated fields to interact and discuss, which is expected to create novel insights as well as lead to more coherence and clarity in the relevant terminology, formats and important research directions in the field.Ĭytoskeletal dynamics is at the core of the most essential questions in cellular neurobiology, such as mechanisms of axon growth in development and in response to injury, or mechanisms of synapse formation and stabilization. EBRAINS is uniquely suited to provide a platform to compare anatomy, physiology and behaviour between species, due to its atlases, numerous datasets, as well as the whole brain models from different species. This workshop brings together experimental and computational scientists whose work allows a comparison of the anatomy and function of the PFC between species (in particular between humans, monkeys and mice). The prefrontal cortex (PFC) is particularly relevant in this regard as its function is poorly understood and potential cross-species differences remain highly debated. Understanding the human brain relies for a large part on work in animal models, which necessitates a careful cross-species comparison.
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